犬の全身吸入麻酔の麻酔前投薬としてのプロピオニール
プロマジンとアセプロマジンの比較

山下和人^†　　小滝雄一　　横山季子　　都築圭子　　前原誠也
瀬野貴弘　　泉澤康晴　　小谷忠生

（2002年7月24日受付・2002年9月17日受理）

要　　　　　約 　 プロピオニールプロマジン（PRP）とアセプロマジン（ACP）の犬の麻酔前投薬としての効果を比較した．犬臨床例にPRP 0.05mg/kg（PRP群;30頭）またはACP 0.05mg/kg（ACP群;30頭）を静脈内投与（IV）で麻酔前投薬し，ケタミン5mg/kg IVで麻酔導入後，50％笑気―50％酸素―セボフルラン吸入麻酔下で外科手術を実施した．両群とも前投薬後には周囲に無関心となり，脱力して伏臥するなど良好な鎮静状態を示した．ケタミン投与直後の一過性の全身性痙攣，麻酔導入後の無呼吸，体温低下および血圧低下などの副作用の発生状況にPRP群とACP群の間に差はなかった．術中の麻酔モニタリング項目の変化にも群間に差はなく，両群とも終末呼気セボフルラン濃度2.0〜2.2％，心拍数120回/分，平均動脈血圧80mmHg，呼吸数25回/分および終末呼気炭酸ガス分圧40mmHg前後で推移した．また，麻酔回復状態にも差はなく，両群とも麻酔終了後10分以内に喉頭反射が回復し，麻酔回復は穏やかであった．PRPは犬の麻酔前投薬としてACPとほぼ同等の効果と副作用を示した． ―キーワード：アセプロマジン，犬，麻酔前投薬，プロピオニールプロマジン． --------------------日獣会誌　55，799〜804（2002） Clinical Comparison between Propionylpromazine and Acepromazine as Premedication for Inhalation Anesthesia of Dogs Kazuto YAMASHITA†, Yuichi KOTAKI, Tokiko YOKOYAMA, Keiko TSUZUKI, Seiya MAEHARA, Takahiro SENO, Yasuharu IZUMISAWA and Tadao KOTANI School of Veterinary Medicine, Rakuno Gakuen University, 582-1 Bunkyodai Midorimachi, Ebetsu 069-8501, Japan SUMMARY 　The effects of propionylpromazine (0.05 mg/kg IV; PRP, n＝30) were compared with those of acepromazine (0.05 mg/kg; ACP, n＝30) as premedication before inhalation anesthesia of dogs. Surgical anesthesia was induced with ketamine 5 mg/kg IV and maintained with 50% nitrous oxide-50% oxygen-sevoflurane. After premedication, all dogs became calm and relaxed and demonstrated moderate sedation. After injections of ketamine, convulsions occurred in 1 dog in the ACP group and in 2 dogs in the PRP group. After induction of anesthesia, apnea occurred in 8 dogs in the ACP group and 10 dogs in the PRP dogs. Controlled ventilation was required to improve ventilation and/or to maintain surgical anesthesia in 7 dogs in the ACP group and 4 dogs in the PRP group. End-tidal sevoflurane concentration during surgery varied between 2.0 and 2.2%. During surgery, body temperatures dropped below 36℃ in 12 dogs in the ACP group and in 13 dogs in the PRP group. Hypothermia (＜35.0℃) developed in 3 dogs in each group. Throughout surgery in both groups, heart rate, respiratory rate and partial pressure of end-tidal CO2 were maintained within normal canine limits: 120 bpm, 25 bpm, and 40 mmHg, respectively. Hypotension occurred in 6 dogs in each group. Recovery from anesthesia was rapid, and most dogs were extubated 10 minutes after anesthesia cessation. No differences between the premedication effects of propionylpromazine and acepromazine were apparent. Both are useful as premedication for dogs. ―Key words : acepromazine, dog, premedication, propionylpromazine. †　Correspondence to : Kazuto YAMASHITA (School of Veterinary Medicine, Rakuno Gakuen University) 582-1 Bunkyodai Midorimachi, Ebetsu 069-8501, Japan TEL・FAX 011-388-4792 --------------------J. Jpn. Vet. Med. Assoc., 55, 799〜804 (2002)