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要 約
犬の乾性角結膜炎（KCS）における0.2％シクロスポリン（CsA）眼軟膏の涙液分泌に及ぼす影響をシルマー涙試験（STT）で評価した．健常成犬4頭とKCSもしくはそれが疑われる成犬16頭（KCS群）を対象とした．対象犬はSTTを用いて4群に分類した．すなわち，健常犬群（STT：15mm/分以上）8眼，I群（STT：0mm/分以上）12眼，II群（STT：1〜5mm/分）7眼，III群（STT：6〜10mm/分）5眼とした．CsA眼軟膏は1日2回6週間点眼した．CsAは健常犬の涙液分泌能には影響を与えず，有意な副作用ももたらさなかった．一方，KCS群にCsAを投与した場合には涙液の有意な分泌増加が認められた．CsA投与前と6週間投与後のSTT値は，I群で0mm/分から3.25±1.10mm/分へ，II群で3.50±0.56mm/分から8.83±1.92mm/分へ，III群で7.80±0.37mm/分から10.00±2.07mm/分へと増加した．さらにCsAはKCS群にみられた角膜光沢の低下，結膜肥厚，眼瞼腫脹，眼の不快感などの臨床症状を改善した．
―キーワード：シクロスポリン，犬，乾性角結膜炎，シルマー涙試験．
--------------------日獣会誌 54，105〜108（2001）
Effects of Cyclosporine Ointment on Lacrimation
in Dogs Suffeering from Kerato-conjunctivitis Sicca
Nobuyuki KANEMAKI†, Yuko YAMAKAWA, Chie KOMATA,
Noriko YAMAMOTO, Kei ONO, Ken ONDA and Yasunori WADA
＊School of Veterinary Medicine, Azabu University,
1-17-71 Fuchinobe, Sagamihara 229-8501，Japan
SUMMARY
Effects of 0.2% cyclosporine (CsA) on lacrimation in dogs suffering from kerato-conjunctivitis
sicca (KCS) were evaluated. Four healthy dogs and 16 adult dogs suffering from KCS were used. On the
basis of the Schirmer tear test (STT), the dogs with KCS were divided into 4 groups: the healthy group
(8 normal eyes with STT values of 15 mm/min or more), Group I(12 eyes with STT values of 0 mm/min), Group
II(7 eyes with STT values of from 1 to 5 mm/min), and Group III (5 eyes with STT values of from 6 to
10 mm/min). The CsA ointment was administered twice a day for 6 weeks. Local administration of CsA had
no effect on lacrimation in the healthy dogs. On the other hand, CsA treatment significantly increased
lacrimation during the experiment in Groups I and II. In all groups, CsA improved such clinical signs
as corneal lusterlessness, conjunctival hypertrophy, blepharo-edema, and ocular discomfort. CsA induced
no adverse side effects in any of the dogs tested.
―Key words : cyclosporine, dogs, kerato-conjunctivitis sicca, Schirmer tear test.
† Nobuyuki KANEMAKI (School of Veterinary Medicine, Azabu University)
1-17-71 Fuchinobe, Sagamihara 229-8501, Japan
TEL 0427-57-7111 FAX 0427-69-1637
--------------------J. Jpn. Vet. Med. Assoc.、54, 105〜108 (2001) |
