乳牛の全身性リポフスチン沈着症の4例

北海道留萌保健所天塩支所ウブシ駐在所（〒098-3311　北海道天塩郡天塩町字ウブシ5324-1）

（1998年11月30日受付・1999年5月10日受理）

要　　　　　約 　廃用と殺されたホルスタイン種乳牛（4歳8カ月〜7歳）4例が全身性リポフスチン沈着症と診断された．ほとんどすべての骨格筋，心筋，肝臓，腎臓，副腎，小腸筋層および大脳皮質の褐色化が認められ，組織学的に，多くの臓器・組織の細胞に，PAS陽性，Sudan黒B染性，抗酸性で，黄橙色蛍光を発する微細あるいは粗大なリポフスチン顆粒が沈着していた．全例の小腸筋層平滑筋線維，3例の横隔膜筋線維，1例の心筋線維には，リポフスチン顆粒に混じて好酸性顆粒あるいは硝子様滴状物（径14μm）が認められた．さらに3例の横隔膜筋では，筋線維中央に位置する自家食胞が観察された．色素沈着を示した神経細胞周囲に膠細胞反応は認められなかった． ―キーワード：乳牛，全身性リポフスチン沈着症． --------------------日獣会誌　52，588〜592（1999） Four Cases of Generalized Lipofuscinosis in Cows Susumu OHFUJI Ubushi substation, Teshio branch of Hokkaido Rumoi Health Centre, 5324-1 Ubushi, Teshio, Hokkaido 098-3311, Japan SUMMARY 　Four Cases of Holstein-Friesian cows, 4 2/3 to 7 years old, were slaughtered due to unfavorable clinical diagnoses such as lumbar paralysis, pelvic trauma, and chronic necrotizing pododermatitis, and were diagnosed as generalized lipofuscinosis. In all cases, most of the skeletal, tongue, masseter and diaphragm muscles were grossly tinged with dark brown, and the cardiac muscle, liver, kidney, adrenal cortex, muscular layer of the small intestines and cerebral cortex were also affected with brown discoloration. Microscopy revealed a generalized intracytoplasmic deposition of fine or coarse granules, tinctorially identical to lipofuscin, which were PAS-positive, sudanophilic, acid fast, and yellowish-orange autofluorescent. The cardiac muscle fibers (1 case)，diaphragm (3 cases)，and intestines (all cases) had intracytoplasmic eosinophilic granules or hyaline droplets of various sizes up to 14μm in diameter. The diaphragmatic muscle fibers (3 cases) had central autophagic vacuoles. No glial reaction was seen around nerve cells containing lipofuscin pigments. ―Key words : cow, generalized lipofuscinosis. --------------------J. Jpn. Vet. Med. Assoc., 52, 588〜592(1999)