1)日本大学松戸歯学部(〒271-0061 松戸市栄町西2-870-1) 2)東京大学農学部(〒113-0032 文京区弥生1-1-1) |
(1998年2月23日受付・1998年12月15日受理)
犬64頭の歯周炎罹患210歯を機械的清掃後,142歯(投与群)には塩酸ミノサイクリン製剤を投与,68歯(対照群)には軟膏基剤を投与したところ,投与群では歯の動揺は1週以降減少して2週以降排膿は認められず,プロービング時の出血率が1週以降著明に減少し,2週以降対照群と比べて有意差が認められた.投与群では3週以降ポケットの深さは有意に改善され,4週後のプラーク再沈着が有意に抑制された. --------------------日獣会誌 52,239〜242(1999)
Clinical Effect of Minocycline Hydrochloride Ointment on Canine PeriodontitisKazuhiko HAYASHI* and Atsuhiko HASEGAWA
SUMMARY Two hundred and ten periodontal pockets of 64 adult dogs with periodontitis were locally treated
with minocycline hydrochloride (PeriocareTM) and observed for a period of 4 weeks. After scaling, root
planing and curettage, 142 pockets were administrated the drug once a week for 4 weeks, and 68 pockets
received the ointment base as controls. Debris index, pocket depth, bleeding on probing and pus discharge
were significantly improved in the treated group at 4 weeks of treating as compared to the control. --------------------J. Jpn. Vet. Med. Assoc., 52, 239〜242 (1999) |